{"id":431,"date":"2012-05-11T19:30:37","date_gmt":"2012-05-11T11:30:37","guid":{"rendered":"http:\/\/192.168.1.11\/?p=431"},"modified":"2024-11-23T11:54:08","modified_gmt":"2024-11-23T03:54:08","slug":"%e8%83%83%e7%99%8c%e7%b4%b0%e8%83%9e%e7%99%bc%e5%b1%95%e5%bd%a2%e6%88%90%e4%b9%8b%e5%88%86%e5%ad%90%e6%a9%9f%e8%bd%89","status":"publish","type":"post","link":"https:\/\/www.tdjj.tw\/?p=431","title":{"rendered":"\u80c3\u764c\u7d30\u80de\u767c\u5c55\u5f62\u6210\u4e4b\u5206\u5b50\u6a5f\u8f49"},"content":{"rendered":"

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\u5929\u5730\u7cbe\u9032\u4e2d\u91ab\u8a3a\u6240\u9662\u9577 \u9678\u5148\u884d \u6574\u7406<\/p>\n

ras<\/em>\u57fa\u56e0<\/strong>\u7684\u9ede\u7a81\u8b8a\u5e38\u898b\u65bc\u4eba\u985e\u816b\u7624\u548c\u764c\u524d\u75c5\u8b8a\u3002p21ras<\/sup>\u86cb\u767d<\/strong>\u5728\u80c3\u5404\u7d1a\u75c5\u8b8a\u4e2d\u5305\u62ec\u6b63\u5e38\u80c3\u9ecf\u819c\u5747\u6709\u8868\u9054\u3002p21ras<\/sup>\u86cb\u767d<\/strong>\u5728\u6162\u6027\u6dfa\u8868\u6027\u80c3\u708e\u3001\u7570\u578b\u589e\u751f\u3001\u80c3\u764c\u4e2d\u967d\u6027\u7387\u5206\u5225\u70ba10 %\uff082\/10\uff09\uff0c20 %\uff084\/20\uff09\uff0c52.5%\uff0821\/40\uff09\uff0c\u5dee\u7570\u6709\u986f\u8457\u6027\uff08p<\/em>\uff1c0.05\uff09\u3002\u5728\u80c3\u764c\u524d\u75c5\u8b8a\u4e2d\uff0c\u4e0d\u5178\u578b\u589e\u751f\u7a0b\u5ea6\u8207p21<\/strong>\u8868\u9054\u91cf\u5bc6\u5207\u76f8\u95dc\uff0c\u8aaa\u660eras<\/em>\u57fa\u56e0<\/strong>\u7684\u6d3b\u5316\u5728\u764c\u8b8a\u904e\u7a0b\u4e2d\u5177\u6709\u91cd\u8981\u4f5c\u7528\uff0c\u96a8\u8457\u589e\u751f\u7a0b\u5ea6\u7684\u52a0\u91cd\uff0c\u5176\u4f5c\u7528\u9010\u6f38\u589e\u5f37\u3002\u6aa2\u6e2c\u767c\u73fe\u80c3\u764cp21<\/strong>\u967d\u6027\u7387\u9ad8\u905482%\uff0c\u80c3\u826f\u6027\u75c5\u8b8a\u53ea\u670935%\uff0c\u6b63\u5e38\u80c3\u9ecf\u819c\u5747\u70ba\u9670\u6027\u3002\u6aa2\u6e2c\u80c3\u8178\u9053\u812b\u843d\u7d30\u80dep21<\/strong>\u767c\u73fe\u60e1\u6027\u816b\u7624\u5168\u90e8\u967d\u6027\uff0c\u826f\u6027\u75be\u75c5\u967d\u6027\u7387\u4e0d\u523010%\u3002<\/p>\n

\u6b63\u5e38\u80c3\u9ecf\u819c\u817a\u9ad4\u9838\u90e8\u5340\u57df\u5076c-myc<\/em>\u57fa\u56e0\u86cb\u767d<\/strong>\u7684\u5f31\u967d\u6027\u8868\u9054\uff0c\u800c\u9ecf\u819c\u7570\u578b\u589e\u751f\u5247\u6709\u8f03\u9ad8\u7684\u8868\u9054\u7387\uff0c\u5728\u8f15\u3001\u4e2d\u3001\u91cd\u5ea6\u7570\u578b\u589e\u751f\u4e2d\u7684\u967d\u6027\u7387\u5206\u5225\u70ba70%\uff0c100 %\uff0c71.4%\uff0c\u4e00\u65e6\u80c3\u9ecf\u819c\u764c\u8b8a\u5f8c\uff0c\u8868\u9054\u7387\u6709\u6240\u4e0b\u964d\uff0c\u5728\u65e9\u671f\u53ca\u9032\u5c55\u671f\u80c3\u764c\u4e2d\u7684\u967d\u6027\u7387\u5206\u5225\u70ba38.9%\u548c73.3%\u3002\u9019\u8868\u660e\u5728\u4e0d\u5178\u578b\u589e\u751f\u75c5\u8b8a\u4e2d\uff0c\u5df1\u6709\u76f8\u7576\u75c5\u4f8b\u5728\u57fa\u56e0\u4e0a\u5df1\u767c\u751f\u4e86\u6539\u8b8a\u3002\u6587\u737b\u5831\u9053\uff0cc-myc<\/em>\u764c\u57fa\u56e0<\/strong>\u8868\u9054\u6c34\u6e96\u6d89\u53ca\u7d30\u80de\u7684\u589e\u6b96\u53ca\u8207\u7d30\u80de\u5206\u88c2\u901f\u7387\u5bc6\u5207\u76f8\u95dc\u3002c-myc<\/em>\u764c\u57fa\u56e0<\/strong>\u7684\u6d3b\u5316\u53ef\u80fd\u662f\u764c\u8b8a\u7684\u524d\u63d0\u689d\u4ef6\u4e4b\u4e00\u3002<\/p>\n

APC<\/em>\u57fa\u56e0<\/strong>\u6700\u521d\u662f\u5728\u7d50\u8178\u817a\u7624\u6027\u606f\u8089\uff08adenomatous polyposis coli\uff09\u60a3\u8005\u4e2d\u767c\u73fe\u7684\uff0c\u4e26\u4ee5\u6b64\u547d\u540d\u3002\u89c0\u5bdf\u80c3\u764c\u524d\u75c5\u8b8a\u4e4bAPC<\/em>\u57fa\u56e0<\/strong>\uff0c\u767c\u73feAPC<\/em>\u57fa\u56e0<\/strong>\u7684\u967d\u6027\u7387\u4ee5\u6b63\u5e38\u9ecf\u819c\u6700\u9ad8\u70ba83.3%\uff0c\u8f15\u4e2d\u3001\u8f15\u3001\u91cd\u7570\u578b\u589e\u751f\u5206\u5225\u70ba77.8%\uff0c67.%\uff0c25.9%\uff0c\u91cd\u5ea6\u8005\u660e\u986f\u4f4e\u65bc\u524d\u5169\u8005\uff0c\u764c\u7d44\u7e54\u5247\u66f4\u4f4e\uff0c\u70ba6.7%-8.2%\u3002\u8178\u4e0a\u76ae\u5316\u751f\u4e2d\uff0cAPC<\/em>\u57fa\u56e0<\/strong>\u967d\u6027\u7387\u5927\u8178\u578b\u9ad8\u65bc\u5c0f\u8178\u578b\uff0c\u4e0d\u5b8c\u5168\u6027\u9ad8\u65bc\u5b8c\u5168\u6027\uff0c\u5927\u8178\u578b\u4e0d\u5b8c\u5168\u6027\u6700\u9ad8\u3002APC<\/em>\u57fa\u56e0<\/strong>LOH \u5373\u53ef\u898b\u65bc\u65e9\u671f\u764c\u3002<\/p>\n

p53<\/em>\u57fa\u56e0<\/strong>\u7570\u5e38\u5728\u80c3\u764c\u5f62\u6210\u904e\u7a0b\u4e2d\u5177\u6709\u91cd\u8981\u4f5c\u7528\uff0c\u5176\u7570\u5e38\u8868\u9054\u51fa\u73fe\u5728\u80c3\u9ecf\u819c\u764c\u8b8a\u7684\u65e9\u671f\u968e\u6bb5\uff0c\u8cab\u7a7f\u6574\u500b\u764c\u8b8a\u9032\u7a0b\u3002\u6b63\u5e38\u9ecf\u819c\u4e0a\u76ae\u7121p53\u86cb\u767d<\/strong>\u8868\u9054\uff0c\u6162\u6027\u6dfa\u8868\u6027\u80c3\u708e\u5076\u898b\u6563\u898b\u5f31\u967d\u6027\u8868\u9054\u3002\u840e\u7e2e\u6027\u80c3\u708e\u3001\u8f15\u5ea6\u4e0d\u5178\u578b\u589e\u751f\u3001\u80c3\u817a\u764c\u6709\u7a0b\u5ea6\u4e0d\u540c\u7684p53 \u86cb\u767d<\/strong>\u7684\u8868\u9054\uff0c\u8868\u9054\u7387\u96a8\u75c5\u8b8a\u52a0\u91cd\u800c\u589e\u9ad8\u3002\u57fa\u56e0\u7570\u5e38\u5ee3\u6cdb\u8868\u9054\u53ef\u51fa\u73fe\u65bc\u80c3\u764c\u524d\u75c5\u8b8a-\u4e0d\u5178\u578b\u589e\u751f\u7684\u4e0a\u76ae\u4e2d\uff0c\u4e0d\u51fa\u73fe\u5728\u5c0f\u8178\u4e0a\u76ae\u5316\u751f\u7684\u4e00\u822c\u6162\u6027\u840e\u7e2e\u6027\u80c3\u708e\u4e2d\u3002\u5b83\u53ef\u80fd\u662f\u80c3\u764c\u524d\u75c5\u8b8a\u7684\u665a\u671f\u6a19\u8a8c\u7269\u4e4b\u4e00\u3002\u7a81\u8b8a\u4e4bp53<\/em>\u57fa\u56e0<\/strong>\u4e0d\u4f46\u55aa\u5931\u4e86\u5176\u6291\u764c\u6d3b\u6027\uff0c\u800c\u4e14\u5177\u6709\u4fc3\u9032\u60e1\u6027\u8f49\u5316\u7684\u4f5c\u7528\u3002p53<\/em><\/strong>\u7a81\u8b8a\u7387\u5728\u8178\u5316\u3001\u4e0d\u5178\u578b\u589e\u751f\u3001\u80c3\u764c\u5206\u5225\u70ba37.1% \uff083\/8\uff09\uff0c42.1%\uff088\/19\uff09\uff0c53.2%\uff0816\/30 )\uff0c\u6b63\u5e38\u7d44\u7e54\uff0c\u6dfa\u8868\u80c3\u708e\u672a\u767c\u73fep53<\/em>\u7a81\u8b8a\u3002<\/p>\n

p16<\/em>\u57fa\u56e0<\/strong>\u53c8\u7a31MTS1<\/em>\uff08multiple tomor suppressor 1\uff09<\/strong>\u6216CDK4I<\/em>\uff08cdk4 inhibitor )<\/strong> \uff0c\u816b\u7624\u6291\u5236\u57fa\u56e0p16<\/em><\/strong>\u7684\u6291\u764c\u4f5c\u7528\u5728\u65bc\u5b83\u6291\u5236\u4e86\u7d30\u80de\u5f9eG1-S\u671f\u8f49\u8b8a\uff0c\u5728\u6b64\u9019\u7a0b\u4e2dCDK4<\/strong>\u5177\u6709\u91cd\u8981\u7684\u89d2\u8272\uff0cp16<\/em>\u57fa\u56e0<\/strong>\u4ee5\u591a\u6a5f\u5236\u53c3\u8207\u816b\u7624\u7684\u767c\u751f\u3002p16\u86cb\u767d<\/strong>\u5728\u6b63\u5e38\u80c3\u9ecf\u819c\u4e0a\u76ae\u4e2d\u5448\u9ad8\u5ea6\u8868\u905486.6%\uff0813\/15\uff09\uff0c\u96a8\u8457\u75c5\u8b8a\u7684\u767c\u5c55\uff0c\u8868\u9054\u7387\u5448\u4e0b\u964d\u8da8\u52e2\uff0c\u8868\u73fe\u70ba\u7a0b\u5ea6\u4e0d\u540c\u7684\u86cb\u767d\u8868\u9054\u7f3a\u5931\uff0c\u9019\u7a2ep16\u86cb\u767d<\/strong>\u8868\u9054\u6c34\u6e96\u7684\u964d\u4f4e\u4ee5\u4e0d\u5178\u578b\u589e\u751f\u75c5\u8b8a\u6700\u70ba\u660e\u986f\uff0c\u8868\u9054\u7387\u905431.8%\uff087\/12\uff09\uff0c\u81f3\u764c\u968e\u6bb5\u7565\u6709\u56de\u5347\uff0c\u4f46\u8f03\u6b63\u5e38\u4e0a\u76ae\uff0c\u6dfa\u8868\u6027\u80c3\u708e\u548c\u840e\u7e2e\u6027\u80c3\u708e\u4ecd\u5448\u660e\u986f\u7684\u4f4e\u8868\u9054\u72c0\u614b\u3002\u80c3\u764c\u7d44\u7e54\u4e2d\u6709\u8f03\u9ad8p16\u57fa\u56e0<\/strong>\u7f3a\u5931\uff0cp16 \u57fa\u56e0<\/strong>\u7f3a\u5931\u8207\u80c3\u764c\u5f62\u6210\u5bc6\u5207\u76f8\u95dc\uff0c\u662f\u80c3\u9ecf\u819c\u764c\u8b8a\u5e38\u898b\u7684\u4e14\u662f\u51fa\u73fe\u8f03\u65e9\u7684\u5206\u5b50\u7570\u5e38\u3002<\/p>\n

MCC<\/em>\u57fa\u56e0<\/strong>\u5373\u7d50\u8178\u764c\u7a81\u8b8a\u57fa\u56e0\uff08mutated in colonectal cancer\uff09\uff0c\u80c3\u764c\u7d44\u7e54\u4e4bMCC<\/em>\u57fa\u56e0<\/strong>\u53ef\u80fd\u53c3\u8207\u80c3\u764c\u7684\u65e9\u671f\u767c\u751f\u968e\u6bb5\u4e4b\u4f5c\u7528\uff0cMCC<\/em>\u57fa\u56e0<\/strong>\u4e4bLOH\u662f\u80c3\u764c\u6700\u5e38\u898b\u7684\u57fa\u56e0\u6539\u8b8a\u4e4b\u4e00\uff0c\u662f\u80c3\u8178\u816b\u7624\u767c\u751f\u7684\u65e9\u671f\u6539\u8b8a\u3002<\/p>\n

bcl-2<\/em>\u57fa\u56e0\u4f4d<\/strong>\u65bc\u7c92\u7dda\u9ad4\uff0c\u5167\u8cea\u7db2\u548c\u6838\u819c\u4e0a\uff0c\u5c6c\u6297\u51cb\u4ea1\u57fa\u56e0\uff0c\u6709\u6291\u5236\u7d30\u80de\u51cb\u4ea1\u7684\u4f5c\u7528\u3002\u6709\u7814\u7a76\u986f\u793abcl-2<\/em>\u57fa\u56e0<\/strong>\u8207\u80c3\u764c\u5bc6\u5207\u76f8\u95dc\u3002\u6162\u6027\u6dfa\u8868\u6027\u80c3\u708ebcl-2<\/strong>\u967d\u6027\u8868\u9054\u7387\u6700\u4f4e10%\uff082\/20\uff09\uff0c\u96a8\u8457\u75c5\u8b8a\u7a0b\u5ea6\u7684\u6f14\u8b8a\u548c\u9032\u5c55\uff0cbcl-2<\/strong>\u967d\u6027\u9010\u6f38\u589e\u5f37\uff0c\u8178\u4e0a\u76ae\u5316\u751fbcl-2<\/strong>\u967d\u6027\u738733.33%\uff0814\/22\uff09\uff0c\u7570\u578b\u589e\u751f58.22 %\uff0820\/34\uff09\uff0c\u80c3\u764c80.26%\uff0861\/76\uff09\uff0c\u5728\u8178\u5316\u751f\u3001\u7570\u578b\u589e\u751f\u5df1\u6709bcl-2<\/strong>\u7570\u5e38\u8868\u9054\uff0c\u610f\u5473\u8457\u80c3\u764c\u8b8a\u7684\u65e9\u671f\u968e\u6bb5\u5df1\u51fa\u73febcl-2<\/strong>\u8abf\u7bc0\u7684\u5931\u63a7\uff0c\u5176\u6a5f\u5236\u662f\u900f\u904e\u6291\u5236\u7d30\u80de\u6b7b\u4ea1\uff0c\u5ef6\u9577\u7d30\u80de\u751f\u547d\u800c\u4f7f\u7d30\u80de\u6578\u91cf\u589e\u591a\uff0c\u5c0e\u81f4\u816b\u7624\u767c\u751f\u3002<\/p>\n","protected":false},"excerpt":{"rendered":"

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