\u9f3b\u54bd\u764c\u7d30\u80de\u767c\u5c55\u5f62\u6210\u4e4b\u5206\u5b50\u6a5f\u8f49<\/p>\n
\u5929\u5730\u7cbe\u9032\u4e2d\u91ab\u8a3a\u6240\u9662\u9577 \u9678\u5148\u884d \u6574\u7406<\/p>\n
\u907a\u50b3\u7269\u8cea\u7684\u6539\u8b8a\u6703\u5f15\u8d77\u7d30\u80de\u7684\u6539\u8b8a\u3002\u9f3b\u54bd\u764c\u7d30\u80de\u907a\u50b3\u7269\u8cea\u7684\u591a\u7a2e\u7570\u5e38\uff0c\u5c0e\u81f4\u9f3b\u54bd\u764c\u7d30\u80de\u4e0d\u540c\u7684\u7d30\u80de\u529f\u80fd\u969c\u7919\u3002<\/p>\n
\u5f9e\u9f3b\u54bd\u764c\u7d44\u7e54\u6216\u7d30\u80de\u4e2d\u5dee\u7570\u8868\u9054\u767c\u73fe\u67d0\u4e9b\u5019\u9078\u6291\u7624\u57fa\u56e0\uff0c\u5982\uff1aSPLUNC1\u3001LPLUNC\u3001NOR1\u3001BRD7\u3001NAG7\u3001UBAP1\u53caNGX6\u7b49\uff0c\u9019\u4e9b\u57fa\u56e0\u5728\u63a7\u5236\u7d30\u80de\u9031\u671f\u9650\u5236\u9ede\u3001\u8abf\u7bc0\u7d30\u80de\u7684\u51cb\u4ea1\u3001\u6291\u5236\u816b\u7624\u7684\u4fb5\u8972\u8207\u8f49\u79fb\u7b49\u8a0a\u865f\u50b3\u5c0e\u901a\u8def\u4e2d\u5177\u6709\u91cd\u8981\u7684\u751f\u7269\u529f\u80fd\u3002\u540c\u6642\uff0c\u7531\u65bc\u9019\u4e9b\u57fa\u56e0\u5728\u9f3b\u54bd\u764c\u7d30\u80de\u6216\u7d44\u7e54\u4e2d\u8868\u9054\u4e0b\u8abf\u6216\u7f3a\u5931\uff0c\u5c0e\u81f4\u4e86\u9f3b\u54bd\u764c\u7d30\u80de\u7684\u4e0d\u540c\u7d30\u80de\u529f\u80fd\u969c\u7919\u3002<\/p>\n
\u7d30\u80de\u9031\u671f\u8abf\u63a7\u5931\u5e38\u662f\u4e00\u500b\u8907\u96dc\u7684\u904e\u7a0b\uff0c\u591a\u500b\u91cd\u8981\u57fa\u56e0\u53c3\u8207\u4e86\u9f3b\u54bd\u764c\u7d30\u80de\u9031\u671f\u8abf\u63a7\u3002BRD7\u662f\u4e00\u500b\u6eb4\u5340\u7d50\u69cb\uff08bromodomain \uff09\u5bb6\u65cf\u6210\u54e1\uff0c\u5e38\u8207\u6838\u86cb\u767dBRD2\u3001BRD3\u4ee5\u8907\u5408\u9ad4\u7684\u5f62\u5f0f\u5b58\u5728\u65bc\u7d30\u80de\u6838\uff0c\u80fd\u7d50\u5408\u548c\u8b58\u5225\u4e59\u91af\u5316\u7d44\u86cb\u767d\uff0c\u662f\u4e00\u500b\u91cd\u8981\u7684\u6838\u86cb\u767d\u56e0\u5b50\u3002\u5728\u9f3b\u54bd\u764c\u7d30\u80de\u4e2d\u904e\u5ea6\u8868\u9054BRD7\uff0c\u7d93\u7531\u6291\u5236ras\/MERK\u548cRb\/E2F\u8a0a\u865f\u901a\u8def\u4e2d\u91cd\u8981\u5206\u5b50\u7684\u6d3b\u6027\u4ee5\u53ca\u4e0b\u8abfcyclinD1\u3001E2F3\u555f\u52d5\u5b50\u7684\u6d3b\u6027\uff0c\u800c\u6291\u5236\u9f3b\u54bd\u764c\u7d30\u80de\u9031\u671f\u9032\u7a0b\u548c\u7d30\u80de\u589e\u6b96\u3002<\/p>\n
\u7814\u7a76\u767c\u73fe\uff0c\u904e\u5ea6\u8868\u9054NGX6 \u80fd\u4e0b\u8abfEGFR ras\/MEK\/MAPK\u901a\u8def\uff0c\u56e0\u800c\u6291\u5236\u7d30\u80de\u9031\u671fG0\u5230G1 \u671f\u7684\u9032\u7a0b\u3002<\/p>\n
\u9f3b\u54bd\u764c\u7d30\u80de\u4e2d\u904e\u5ea6\u8868\u9054NAG7 \u57fa\u56e0\u80fd\u4e0a\u8abf\u7d30\u80de\u9031\u671f\u76f8\u95dc\u57fa\u56e0GASP ( growth arrest specific protein\uff09\u7684\u8868\u9054\u3001\u4e0b\u8abf\u7d30\u80de\u9031\u671f\u7d20cyclin D1\u3001cyclin E\u548c\u7d30\u80de\u9031\u671f\u76f8\u95dc\u86cb\u767dRab-36( ras-related protein rab-36\uff09\u7684\u8868\u9054\uff0c\u4e26\u56e0\u6b64\u5ef6\u7de9\u7d30\u80deG1\u81f3S\u671f\u7684\u9032\u7a0b\uff0c\u56e0\u800c\u6291\u5236\u9f3b\u54bd\u764c\u7d30\u80de\u7684\u589e\u6b96\u3002<\/p>\n
\u9f3b\u54bd\u764c\u7d30\u80de\u4e2d\u5118\u7ba1\u82e5\u7121p53 \u7684\u7a81\u8b8a\uff0c\u4f46\u7531\u65bcp14\u5931\u53bb\u6d3b\u6027\u4ee5\u53caN\u7aef\u7f3a\u5931\u7684p63 \u540c\u5206\u7570\u69cb\u9ad4\u7684\u904e\u5ea6\u8868\u9054\uff0c\u6700\u7d42\u5c0e\u81f4\u9f3b\u54bd\u764c\u7d30\u80dep53 \u901a\u8def\u969c\u5f97\u3002<\/p>\n
\u9664\u4e86\u7d30\u80de\u9031\u671f\u8abf\u63a7\u969c\u7919\u4ee5\u5916\uff0c\u9f3b\u54bd\u764c\u7d30\u80de\u9084\u5b58\u5728\u7d30\u80de\u51cb\u4ea1\u3001\u7d30\u80de\u9ecf\u9644\u548c\u7d30\u80de\u9593\u9699\u9023\u63a5\u901a\u8a0a\u80fd\u529b\u7b49\u591a\u7a2e\u529f\u80fd\u7684\u7570\u5e38\u3002<\/p>\n
BRD7\u8207 BRD2\u4ea4\u4e92\u4f5c\u7528\uff0c\u5171\u540c\u4fc3\u9032\u9f3b\u54bd\u764c\u7d30\u80de\u7684\u51cb\u4ea1\uff0c\u986f\u793a\u9f3b\u54bd\u764c\u7d30\u80de\u4e2dBRD7\u548cBRD2\u8868\u9054\u4e0b\u8abf\u6216\u7f3a\u5931\u662f\u9f3b\u54bd\u764c\u7d30\u80de\u51cb\u4ea1\u969c\u7919\u7684\u56e0\u7d20\u4e4b\u4e00\u3002<\/p>\n
Bcl2\u3001MT ( metallothionein \uff09\u548cIdl\u57fa\u56e0\u7684\u8868\u9054\u5728\u9f3b\u54bd\u764c\u4e2d\u6301\u7e8c\u6027\u4e0a\u8abf\u986f\u793a\uff1a\u51cb\u4ea1\u61c9\u7b54\u7684\u6539\u8b8a\u662f\u9f3b\u54bd\u764c\u7d30\u80de\u76f8\u95dc\u8f49\u5316\u901a\u8def\u4e2d\u7684\u65e9\u671f\u4e8b\u4ef6\u3002<\/p>\n
\u5728\u9f3b\u54bd\u764c\u7d30\u80de\u4e2d\u904e\u5ea6\u8868\u9054NGX6\u57fa\u56e0\u80fd\u4e0a\u8abfezrin\u3001nm23\uff0c\u4e0b\u8abf\u03b1-catinin\u7b49\u9ecf\u9644\u5206\u5b50\u7684\u8868\u9054\uff0c\u63d0\u9ad8\u7d30\u80de\u9ecf\u9644\u548c\u9593\u9699\u9023\u63a5\u901a\u8a0a\u80fd\u529b\uff0c\u9032\u800c\u6291\u5236\u9f3b\u54bd\u764c\u7d30\u80de\u7684\u4fb5\u8972\u8207\u8f49\u79fb\u80fd\u529b\u3002<\/p>\n
UBAP1 \u57fa\u56e0\u5305\u542b2\u500b\u9032\u5316\u4e0a\u9ad8\u5ea6\u4fdd\u5b88\u7684UBA \u7d50\u69cb\u5340\uff0c\u5176\u7de8\u78bc\u86cb\u767d\u70ba\u6838\u86cb\u767d\uff0c\u662f\u6cdb\u80bd\u76f8\u95dc\u86cb\u767d\u5bb6\u65cf\u7684\u65b0\u6210\u54e1\u3002UBAP1\u57fa\u56e0\u5728\u9f3b\u54bd\u764c\u4e2d\u8868\u9054\u4e0a\u8abf\uff0c\u4e26\u6709\u660e\u986f\u7684\u6838\u819c\u805a\u96c6\u73fe\u8c61\uff0c\u986f\u793aUBAP1\u57fa\u56e0\u5728\u9f3b\u54bd\u764c\u7d30\u80de\u4e2d\u7684\u5dee\u7570\u8868\u9054\u800c\u5c0e\u81f4\u6cdb\u7d20-\u86cb\u767d\u9176\u9ad4\u901a\u8def\u7570\u5e38\u8207\u9f3b\u54bd\u764c\u7684\u767c\u751f\u767c\u5c55\u76f8\u95dc\u806f\u3002<\/p>\n
\u9f3b\u54bd\u764c\u7684\u767c\u751f\u767c\u5c55\u6d89\u53ca\u591a\u500b\u8a0a\u606f\u901a\u8def\uff0c\u4e0a\u8ff0\u7814\u7a76\u7684\u57fa\u56e0\u9664\u6d89\u53ca\u9f3b\u54bd\u764c\u7d30\u80de\u9031\u671f\u3001\u7d30\u80de\u51cb\u4ea1\u53ca\u7d30\u80de\u9ecf\u9644\u7b49\u8a0a\u606f\u5206\u5b50\u901a\u8def\u4ee5\u5916\uff0c\u53ef\u80fd\u9084\u6d89\u53ca\u591a\u500b\u5176\u4ed6\u901a\u8def\uff0c\u7814\u7a76\u4e0a\u8ff0\u5df1\u77e5\u57fa\u56e0\u548c\u767c\u73fe\u65b0\u7684\u6d89\u53ca\u9f3b\u54bd\u764c\u7d30\u80de\u8840\u7ba1\u751f\u6210\u3001\u4fb5\u8972\u8207\u8f49\u79fb\uff0c\u4ee5\u53ca\u514d\u75ab\u9003\u9038\u7b49\u76f8\u95dc\u8a0a\u606f\u5206\u5b50\u901a\u8def\uff0c\u5c07\u662f\u672a\u4f86\u9032\u4e00\u6b65\u7684\u7814\u7a76\u76ee\u6a19\u3002<\/p>\n","protected":false},"excerpt":{"rendered":"
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\u5929\u5730\u7cbe\u9032\u4e2d\u91ab\u8a3a\u6240\u9662\u9577 \u9678\u5148\u884d<\/p>\n
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