{"id":277,"date":"2012-03-17T16:25:24","date_gmt":"2012-03-17T08:25:24","guid":{"rendered":"http:\/\/192.168.1.11\/?p=277"},"modified":"2021-12-29T16:46:54","modified_gmt":"2021-12-29T08:46:54","slug":"%e9%9d%9e%e5%b0%8f%e7%b4%b0%e8%83%9e%e8%82%ba%e7%99%8c%e4%b8%ad%e9%86%ab%e8%87%a8%e5%ba%8a%e7%a0%94%e7%a9%b6%e9%80%b2%e5%b1%95","status":"publish","type":"post","link":"https:\/\/www.tdjj.tw\/?p=277","title":{"rendered":"\u975e\u5c0f\u7d30\u80de\u80ba\u764c\u4e2d\u91ab\u81e8\u5e8a\u7814\u7a76\u9032\u5c55"},"content":{"rendered":"<p style=\"text-align: center;\">\u975e\u5c0f\u7d30\u80de\u80ba\u764c\u4e2d\u91ab\u81e8\u5e8a\u7814\u7a76\u9032\u5c55<\/p>\n<p style=\"text-align: right;\">\u5929\u5730\u7cbe\u9032\u4e2d\u91ab\u8a3a\u6240\u9662\u9577 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regression analysis\uff09\u3002\u7d50\u679c\u986f\u793a\u4e2d\u91ab\u7d44\u3001\u4e2d\u91ab\u52a0\u5316\u7642\u7d44\u76f8\u5c0d\u65bc\u5316\u7642\u7d44\u5c0d\u751f\u5b58\u671f\u7684\u5f71\u97ff\u5177\u6709\u7d71\u8a08\u5b78\u4e0a\u7684\u610f\u7fa9\uff0c\u5176\u98a8\u96aa\u6bd4\u5206\u5225\u70ba0.479\u30010.446\uff0c\u986f\u793a\u76f8\u5c0d\u65bc\u5316\u7642\u7d44\u53ef\u964d\u4f4e52.1%\u53ca55.4%\u7684\u6b7b\u4ea1\u98a8\u96aa\u3002<\/li>\n<li>\u5468\u5ef6\u5cf0\u7b49[8]\u5c0d90\u4f8bIII-IV\u671fNSCLC\u60a3\u8005\u9032\u884c\u96a8\u6a5f\u5c0d\u7167\u7814\u7a76\u3002\u5316\u7642\u52a0\u4e2d\u85e5\u7d44\u3001\u4e2d\u85e5\u7d44\u3001\u5316\u7642\u7d440.5\u5e74\u751f\u5b58\u7387\u5206\u5225\u70ba90.00%\u300186.67%\u300166.67%\uff08<em>P<\/em>&lt;0.05\uff09\uff0c1\u5e74\u751f\u5b58\u7387\u5206\u5225\u70ba83.33%\u300173.33%\u300153.33%\uff08<em>P<\/em>&lt;0.05\uff09\u3002\u986f\u793a\u4e2d\u85e5\u52a0\u5316\u7642\u7d44\u6216\u662f\u4e2d\u85e5\u7d44\u6cbb\u7642NSCLC\u5c0d\u65bc\u5ef6\u9577\u751f\u5b58\u6642\u9593\u7684\u6548\u679c\u660e\u986f\u512a\u65bc\u5316\u7642\u7d44\u3002<\/li>\n<li>\u90ed\u5349\u7b49[40]\u5c0760\u4f8b\u4e2d\u665a\u671f\u975e\u5c0f\u7d30\u80de\u80ba\u764c\u60a3\u8005\u96a8\u6a5f\u5206\u6210\u6cbb\u7642\u7d44\uff08\u9577\u6625\u745e\u6ff1+\u9806\u9251+\u897f\u9ec3\u4e38\uff09\u8207\u5c0d\u7167\u7d44\uff08\u9577\u6625\u745e\u6ff1+\u9806\u9251\uff09\u540430\u4f8b\u3002\u7d50\u679c\u767c\u73fe\u6cbb\u7642\u7d441\u5e74\u751f\u5b58\u671f15\u4f8b\uff0c2\u5e74\u751f\u5b58\u671f8\u4f8b\uff1b\u5c0d\u7167\u7d441\u5e74\u751f\u5b58\u671f13\u4f8b\uff0c2\u5e74\u751f\u5b58\u671f5\u4f8b\uff0c\u5169\u7d44\u6bd4\u8f03\u6709\u986f\u8457\u5dee\u7570\u3002<\/li>\n<li>\u9673\u92b3\u6df1\u7b49[42]\u9078\u64c7320\u4f8b\u4e2d\u665a\u671f\u975e\u5c0f\u7d30\u80de\u80ba\u764c\u60a3\u8005\uff0c\u63a1\u7528\u81ea\u64ec\u4ed9\u9b5a\u6e6f\u70ba\u57fa\u672c\u65b9\u8fa8\u8b49\u8ad6\u6cbb\u52a0\u6e1b\u6cbb\u7642\uff0c\u9023\u7e8c\u670d\u75281\u500b\u7642\u7a0b\u9032\u884c\u7642\u6548\u8a55\u50f9\u3002\u89c0\u5bdf\u60a3\u8005\u751f\u5b58\u671f\uff0c\u534a\u5e74\u30011\u5e74\u30012\u5e74\u30013\u5e74\u30014\u5e74\u30015\u5e74\u751f\u5b58\u7387\u5206\u5225\u70ba85%\u300153.2%\u300131%\u300111%\u30016%\u30013%\u3002<\/li>\n<li>\u859b\u6696\u73e0\u7b49[9]\u5c0d104\u4f8b\u665a\u671f\u975e\u5c0f\u7d30\u80de\u80ba\u764c\u901a\u904e\u56de\u9867\u6027\u81e8\u5e8a\u5c0d\u7167\u7814\u7a76\u3002\u4e2d\u91ab\u7d44\u4e2d\u4f4d\u751f\u5b58\u671f\u70ba8.0\u00b11.2\u500b\u6708\uff0c\u534a\u5e74\u30011\u5e74\u30012\u5e74\u751f\u5b58\u7387\u5206\u5225\u70ba60.38%\u300124.53%\u30013.77%\uff0c\u897f\u91ab\u7d44\u4e2d\u4f4d\u751f\u5b58\u671f\u70ba5.9\u00b10.4\u500b\u6708\uff0c\u534a\u5e74\u30011\u5e74\u30012\u5e74\u751f\u5b58\u7387\u5206\u5225\u70ba41.18%\u300115.69%\u30011.96%\u3002\u986f\u793a\u4e2d\u91ab\u7d44\u751f\u5b58\u671f\u660e\u986f\u9577\u65bc\u897f\u91ab\u7d44\uff0c\u5728\u5e72\u9810\u6cbb\u7642\u5f8c\u81f3\u96a8\u8a2a\u7684\u524d15\u500b\u6708\u5167\uff0c\u4e2d\u91ab\u7d44\u4e00\u76f4\u7dad\u6301\u8457\u660e\u986f\u9ad8\u65bc\u897f\u91ab\u7d44\u7684\u751f\u5b58\u7387\uff0c\u53ef\u898b\u4e2d\u91ab\u85e5\u6cbb\u7642\u7684\u9060\u671f\u7642\u6548\u512a\u65bc\u897f\u91ab\u6cbb\u7642\u3002<\/li>\n<li>\u7fdf\u9577\u96f2\u7b49[49]\u89c0\u5bdf60\u4f8b\u665a\u671f\u975e\u5c0f\u7d30\u80de\u80ba\u764c\u60a3\u8005\uff0c\u96a8\u6a5f\u5206\u6210\u6cbb\u7642\u7d44\uff08\u4e2d\u85e5+\u5316\u7642\uff0cn=30\uff09\u53ca\u5c0d\u7167\u7d44\uff08\u5316\u7642\uff0cn=30\uff09\uff0c\u6cbb\u7642\u524d\u5169\u7d44\u8cc7\u6599\u7121\u986f\u8457\u5dee\u7570\u3002\u6cbb\u7642\u5f8c\u9060\u671f\u751f\u5b58\u60c5\u6cc1\uff0c\u6cbb\u7642\u7d44\u751f\u5b581\u5e74\u4ee5\u4e0a25\u4f8b\uff0c2\u5e74\u4ee5\u4e0a16\u4f8b\uff0c\u751f\u5b58\u7387\u5206\u5225\u70ba83.33%\uff0c53.33%\uff1b\u5c0d\u7167\u7d44\u751f\u5b581\u5e74\u4ee5\u4e0a10\u4f8b\uff0c2\u5e74\u4ee5\u4e0a7\u4f8b\uff0c\u751f\u5b58\u7387\u5206\u5225\u70ba33.33%\uff0c23.33%\uff0c\u5169\u7d44\u751f\u5b58\u671f\u76f8\u6bd4\u8f03\u6709\u986f\u8457\u5dee\u7570\uff08<em>P<\/em>&lt;0.05\uff09\u3002 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matrix, ECM\uff09\u548c\u57fa\u5e95\u819c\uff08basal membrane, BM\uff09\u7684\u964d\u89e3\u662f\u816b\u7624\u7d30\u80de\u80fd\u5426\u5f62\u6210\u8f49\u79fb\u7684\u95dc\u9375\u6b65\u9a5f\u3002\u76ee\u524d\u7814\u7a76\u8a8d\u70ba\u57fa\u8cea\u91d1\u5c6c\u86cb\u767d\u8122\uff08matrix metalloproteinases, MMPs\uff09\u7cfb\u7d71\u662f\u53c3\u8207\u6b64\u904e\u7a0b\u7684\u6700\u91cd\u8981\u7684\u8122\u7cfb\u7d71[43]\u3002\u800cMMP-2\uff08\u660e\u81a0\u8122A\uff0c\u5206\u5b50\u91cf72kU\uff09\u53ef\u9078\u64c7\u6027\u964d\u89e3\u57fa\u5e95\u819c\u7684\u4e3b\u8981\u6210\u4efdIV\u81a0\u539f\uff0c\u5728\u816b\u7624\u7d30\u80de\u7a81\u7834\u57fa\u5e95\u819c\u5c4f\u969c\u800c\u767c\u751f\u6d78\u6f64\u548c\u8f49\u79fb\u7684\u904e\u7a0b\u4e2d\u626e\u6f14\u91cd\u8981\u89d2\u8272\uff0c\u5b83\u7684\u6d3b\u6027\u53d7\u5230TIMP-2\u7684\u8abf\u63a7\u3002\u8212\u7426\u747e\u7b49[44]\u96a8\u6a5f\u5c0740\u4f8b\u975e\u5c0f\u7d30\u80de\u80ba\u764c\u60a3\u8005\u5206\u6210\u5c0d\u7167\u7d44\uff08\u9d09\u81bd\u5b50\u4e73\u6db2\u6ce8\u5c04\u6db2+TP\u65b9\u6848\uff09\u53ca\u6cbb\u7642\u7d44\uff08\u55ae\u7d14TP\u65b9\u6848\uff09\u540420\u4f8b\u3002\u7d50\u679c\u767c\u73fe\u6cbb\u7642\u7d44\u4e0b\u8abfMMP-2\u53ca\u4e0a\u8abfTIMP-2\u4f5c\u7528\u8f03\u5c0d\u7167\u7d44\u986f\u8457\uff0c<em>P<\/em>&lt;0.05\u3002\u986f\u793a\u9d09\u81bd\u5b50\u4e73\u5291\u6ce8\u5c04\u6db2\u5177\u6709MMP\u6291\u5236\u7269\u6a23\u4f5c\u7528\u3002<\/li>\n<li>\u8fd1\u5e74\u4f86\u7814\u7a76\u8868\u660e\uff0c\u8840\u7ba1\u751f\u6210\u8207\u975e\u5c0f\u7d30\u80de\u80ba\u764c\u7684\u4fb5\u8972\u8207\u8f49\u79fb\u6709\u5bc6\u5207\u95dc\u4fc2\uff0c\u6291\u5236\u816b\u7624\u8840\u7ba1\u751f\u6210\u70ba\u6cbb\u7642\u975e\u5c0f\u7d30\u80de\u80ba\u764c\u7684\u4e00\u7a2e\u65b0\u7684\u9014\u5f91\uff0c\u8a31\u591a\u5be6\u9a57\u8b49\u660e\u4e2d\u91ab\u85e5\u53ef\u6291\u5236\u764c\u7624\u751f\u9577\u8207\u8f49\u79fb\uff0c\u800c\u6291\u5236\u816b\u7624\u8840\u7ba1\u751f\u6210\u70ba\u53ef\u80fd\u9014\u5f91\u4e4b\u4e00\u3002\u7530\u83f2\u7b49[15]\u5c0d126\u4f8b\u975e\u5c0f\u7d30\u80de\u80ba\u764c\u60a3\u8005\u9032\u884c\u96a8\u6a5f\u5206\u7d44\u7814\u7a76\uff0c\u89c0\u5bdf\u4e2d\u85e5\u80ba\u4e00\u4e38\u5c0d\u8840\u7ba1\u5167\u76ae\u751f\u6210\u56e0\u5b50\uff08VEGF\uff09\u3001\u816b\u7624\u7279\u7570\u6027\u751f\u9577\u56e0\u5b50\uff08TSGF\uff09\u5206\u6ccc\u7684\u5f71\u97ff\u53ca\u6291\u5236\u4e2d\u665a\u671f\u975e\u5c0f\u7d30\u80de\u80ba\u764c\u4fb5\u8972\u8f49\u79fb\u7684\u81e8\u5e8a\u7642\u6548\u3002\u5be6\u9a57\u986f\u793a\u670d\u7528\u80ba\u4e00\u4e38\u914d\u5408\u5316\u7642\u7684\u60a3\u8005\uff0c\u5176CR+PR+NP\u53ef\u905479.17%\uff0c\u4e26\u80fd\u6e1b\u4f4e\u5316\u7642\u526f\u4f5c\u7528\uff0c\u6539\u5584\u81e8\u5e8a\u75c7\u72c0\uff0c\u63d0\u9ad8\u751f\u6d3b\u54c1\u8cea\uff0c\u5176\u8840\u6e05VEGF\u3001TSGF\u6c34\u5e73\u986f\u8457\u4e0b\u964d\uff0c\u764c\u7624\u8f49\u79fb\u6e1b\u5c11\u767c\u751f\u3002\u986f\u793a\u80ba\u4e00\u4e38\u6cbb\u7642\u975e\u5c0f\u7d30\u80de\u80ba\u764c\u7684\u5404\u7a2e\u4f5c\u7528\uff0c\u5176\u4e2d\u6291\u5236\u8f49\u79fb\u7684\u90e8\u4efd\u53ef\u80fd\u662f\u900f\u904e\u6291\u5236\u8840\u6e05\u4e2dVEGF\u3001TSGF\u800c\u7522\u751f\u7684\u3002<\/li>\n<li>TGF\u03b2<sub>1<\/sub>\u523a\u6fc0\u816b\u7624\u8840\u7ba1\u751f\u6210\u7684\u4f5c\u7528\u662f\u901a\u904e\u65c1\u5206\u6ccc\u9014\u5f91\u8a98\u5c0eVEGF\u7684\u8868\u9054\u9593\u63a5\u7684\u8a98\u5c0e\u816b\u7624\u8840\u7ba1\u7684\u751f\u6210[16,17]\u3002\u7530\u975c\u7b49[18]\u572858\u540d\u4e2d\u665a\u671f\u975e\u5c0f\u7d30\u80de\u80ba\u764c\u524d\u77bb\u6027\u96a8\u6a5f\u5c0d\u7167\u7684\u7814\u7a76\u4e2d\u3002\u767c\u73fe\u76ca\u6c23\u990a\u9670\u4e2d\u85e5\u53ef\u6291\u5236\u4e2d\u665a\u671f\u975e\u5c0f\u7d30\u80de\u80ba\u764c\u8840\u6e05TGF\u03b2<sub>1<\/sub>\u8868\u9054\u6c34\u5e73\u7684\u589e\u9ad8\uff0c\u4e26\u6291\u5236\u8840\u6e05VEGF\u4e4b\u8868\u9054\u3002<\/li>\n<li>\u5f35\u5fae\u5fae\u7b49[34]\u5c0742\u4f8b\u60a3\u8005\u96a8\u6a5f\u5206\u70ba\u5c0d\u7167\u7d44\uff08\u5316\u7642\uff09\u548c\u7d9c\u5408\u7d44\uff08\u6276\u6b63\u6291\u764c\u65b9+\u5316\u7642\uff09\uff0c21\u5929\u70ba1\u9031\u671f\uff0c\u5169\u7d44\u5747\u9023\u7e8c\u6cbb\u76422\u9031\u671f\u3002\u767c\u73fe\u8840\u6e05TSGF\u6c34\u5e73\u5728\u7b2c2\u9031\u671f\u672b\u7d9c\u5408\u7d44\u4e0b\u964d\u5e45\u5ea6\u986f\u8457\u5927\u65bc\u5c0d\u7167\u7d44\uff08<em>P<\/em>&lt;0.05\uff09\u3002<\/li>\n<li>\u5728\u6b63\u5e38\u6a5f\u9ad4\u5167\uff0csIL-2R\u542b\u91cf\u6975\u5fae\uff0c\u800c\u80ba\u764c\u60a3\u8005sIL-2R\u542b\u91cf\u986f\u8457\u589e\u9ad8\uff0c\u5728\u764c\u7d30\u80de\u523a\u6fc0\u4e0b\uff0c\u6a5f\u9ad4T\u6dcb\u5df4\u7d30\u80de\u6d3b\u5316\uff0c\u5206\u6ccc\u5927\u91cf\u7684sIL-2R\u5165\u8840\uff0c\u5c0e\u81f4IL-2\u7684\u6d3b\u6027\u53d7\u5230\u6291\u5236\uff0c\u6a5f\u9ad4\u514d\u75ab\u529f\u80fd\u4f4e\u4e0b[24]\u3002\u674e\u70af\u7b49[25]\u767c\u73fe\u5728\u570d\u624b\u8853\u671f\u975e\u5c0f\u7d30\u80de\u80ba\u764c\u60a3\u8005\u7d66\u4e88\u4e2d\u85e5\u76ca\u6c23\u990a\u9670\u65b9\u3002\u6cbb\u7642\u7d44\u5728\u6cbb\u7642\u7d50\u675f\u5f8c\uff0cIL-2\u6709\u5927\u5e45\u5ea6\u7684\u63d0\u9ad8\uff0csIL-2R\u4e5f\u6709\u8f03\u5927\u5e45\u5ea6\u5730\u964d\u4f4e\uff0c\u6cbb\u7642\u524d\u5f8c\u6709\u986f\u8457\u5dee\u7570\uff08<em>P<\/em>&lt;0.05\uff09\uff0c\u5c0d\u7167\u7d44\u8207\u6cbb\u7642\u7d44\u6cbb\u7642\u5f8cIL-2\u3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08\u5eb7\u840a\u7279\u6ce8\u5c04\u6db2+\u53e3\u670d\u4e2d\u85e5\uff09\u5f8c\uff0c\u6e2c\u5b9aT\u7d30\u80de\u4e9e\u7fa4\u3002\u767c\u73feCD3<sup>+<\/sup>\u3001CD4<sup>+<\/sup>\u6709\u986f\u8457\u5347\u9ad8\uff0cCD8<sup>+<\/sup>\u6709\u986f\u8457\u964d\u4f4e\uff0cCD4\/CD8\u986f\u8457\u5347\u9ad8\u3002\u986f\u793a\u4e2d\u91ab\u85e5\u7d9c\u5408\u6cbb\u7642\u80fd\u63d0\u9ad8\u6a5f\u9ad4\u7684\u514d\u75ab\u529f\u80fd\u3002<\/li>\n<li>\u8303\u5c0f\u7d05\u7b49[21,22]\u767c\u73fe\uff0c\u80ba\u764c\u7d44\u7e54\u4e2d\u6a39\u7a81\u7d30\u80de\uff08Dendritic cell\uff1bDC\uff09\u5206\u5e03\u5bc6\u5ea6\u8207NSCLC\u81e8\u5e8a\u671f\u6b21\u5448\u660e\u986f\u8ca0\u76f8\u95dc\uff0c\u4e26\u9032\u4e00\u6b65\u8b49\u5be6NSCLC\u5916\u5468\u8840\u4e2dDC\u5206\u5316\u56b4\u91cd\u7f3a\u9677\u3002\u4f55\u6b23\u7b49[23]\u767c\u73fe\u4e2d\u85e5\u914d\u5408\u5316\u7642\u6cbb\u7642\u975e\u5c0f\u7d30\u80de\u80ba\u764c\u80fd\u6e1b\u5c11\u8f49\u79fb\uff0c\u63d0\u9ad8\u751f\u5b58\u8cea\u91cf\uff0c\u5176\u7642\u6548\u6a5f\u5236\u53ef\u80fd\u8207\u63d0\u9ad8\u6a39\u7a81\u72c0\u7d30\u80de\u6578\u91cf\u6709\u95dc\u3002<\/li>\n<li>\u975e\u5c0f\u7d30\u80de\u80ba\u764c\u60a3\u8005\u6e05\u6668\uff08\u5bc5\u536f\u6642\uff09\u6c23\u8840\u884c\u81f3\u80ba\u7d93\u6642\u75c7\u72c0\u52a0\u91cd\uff0c\u8aaa\u660e\u6c23\u8840\u884c\u81f3\u80ba\u7d93\u7684\u6642\u8fb0\uff08\u5bc5\u536f\u6642\uff09\u662f\u80ba\u764c\u60a3\u8005\u6cbb\u7642\u6700\u654f\u611f\u7684\u6642\u8fb0\u3002\u5f35\u9706\u7b49[36]\u89c0\u5bdf\u4e0d\u540c\u6642\u9593\u4f7f\u7528\u53c3\u9ea5\u6ce8\u5c04\u6db2\u5c0d\u975e\u5c0f\u7d30\u80de\u80ba\u764c\u60a3\u8005\u5316\u7642\u7684\u5f71\u97ff\u3002\u7d50\u679c\u767c\u73fe\u5bc5\u6642\u7d44\u816b\u7624\u5ba2\u89c0\u7642\u6548\u3001\u5361\u6c0f\u8a55\u5206\uff08KPS\uff09\u3001EORTC 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\u5289\u81f3\u6771\uff0c\u8a31\u7d39\u767c\uff0c\u97d3\u6bc5\uff0c\u7b49\u300270\u6b72\u4ee5\u4e0a\u8001\u5e74\u4eba\u80ba\u764c273\u4f8b\u7684\u5916\u79d1\u6cbb\u7642\u3002<em>\u7d50\u6838\u75c5\u8207\u80f8\u90e8\u816b\u7624<\/em>\uff0c2005\uff0c3\uff0c183-86<\/p>\n<p>2. \u6731\u6c34\u6ce2\uff0c\u6bb7\u6842\u6797\uff0c\u5f35\u6bbf\u5802\uff0c\u7b49\u3002\u8001\u5e74\u4eba\u80ba\u764c\u7684\u5916\u79d1\u6cbb\u7642\u3002<em>\u897f\u5357\u570b\u9632\u91ab\u85e5<\/em>\uff0c2005\uff0c15(1):40-41<\/p>\n<p>3. \u590f\u9e97\uff0c\u66fe\u7e41\u69ae\u3002\u8001\u5e74\u975e\u5c0f\u7d30\u80de\u80ba\u764c\u7684\u5316\u7642\u73fe\u72c0\u8207\u9032\u5c55\u3002<em>\u4e2d\u570b\u85e5\u696d<\/em>\uff0c2005\uff0c14(6):23-25<\/p>\n<p>4. \u962e\u5ee3\u6b23\uff0c\u5468\u857e\u3002\u8001\u5e74\u975e\u5c0f\u7d30\u80de\u80ba\u764c\u6cbb\u7642\u9032\u5c55\u3002<em>\u907c\u5be7\u4e2d\u91ab\u85e5\u5927\u5b78\u5b78\u5831<\/em>\uff0c2007\uff0c9(5):81-83<\/p>\n<p>5. \u6e6f\u83ef\uff0c\u738b\u5efa\u83ef\uff0c\u9678\u5fe0\u83ef\uff0c\u7b49\u3002\u5e38\u898f\u52a0\u4e09\u7dad\u9069\u5f62\u653e\u5c04\u6cbb\u7642\u8001\u5e74\u4eba\u975e\u5c0f\u7d30\u80de\u80ba\u764c\u81e8\u5e8a\u5206\u6790\u3002<em>\u868c\u57e0\u91ab\u5b78\u9662\u5b78\u5831<\/em>\uff0c2005\uff0c30(6):509-511<\/p>\n<p>6. \u5468\u5cb1\u7ff0\uff0c\u6797\u9e97\u73e0\uff0c\u5468\u5b9c\u5f37\uff0c\u7b49\u3002\u4e2d\u91ab\u85e5\u6cbb\u7642III~IV\u671f\u975e\u5c0f\u7d30\u80de\u80ba\u764c\u7684\u9810\u5f8c\u56e0\u7d20\u5206\u6790\u3002<em>\u300a\u764c\u75c7\u300b<\/em><em>Chinese journal of cancer<\/em>\uff0c2005\uff0c24(10):1252-1256<\/p>\n<p>7. \u674e\u6842\uff0c\u5f35\u66f8\u6668\uff0c\u694a\u9e97\u975c\uff0c\u7b49\u3002\u4e7e\u5764\u81a0\u56ca\u5c0d\u975e\u5c0f\u7d30\u80de\u80ba\u764c\u60a3\u8005\u751f\u5b58\u8cea\u91cf\u53ca\u8840\u6db2TGF-\u03b1\u542b\u91cf\u8b8a\u5316\u7684\u5f71\u97ff\u3002<em>\u5c71\u6771\u4e2d\u91ab\u96dc\u8a8c<\/em>\uff0c2006\uff0c25(5):308-311<\/p>\n<p>8. 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\u5411\u7406\u5b8f\uff0c\u7fdf\u7389\u73cd\uff0c\u5f35\u9ece\uff0c\u7b49\u3002\u76ca\u6c23\u6d3b\u8840\u6e6f\u6cbb\u7642\u665a\u671f\u975e\u5c0f\u7d30\u80de\u80ba\u764c\u81e8\u5e8a\u7642\u6548\u89c0\u5bdf\u3002<em>\u907c\u5be7\u4e2d\u91ab\u96dc\u8a8c<\/em>\uff0c2008\uff0c35(9):1375-1376<\/p>\n<p>21. \u6c5f\u66c9\u4e30\uff0c\u8463\u5f37\u525b\uff0c\u99ae\u4e45\u8ce2\uff0c\u7b49\u3002\u975e\u5c0f\u7d30\u80de\u80ba\u764c\u7d44\u7e54\u4e2d\u8840\u7ba1\u5167\u76ae\u751f\u9577\u56e0\u5b50\u8207\u6a39\u7a81\u72c0\u7d30\u80de\u5206\u5e03\u7684\u95dc\u4fc2\u3002<em>\u816b\u7624<\/em>\uff0c2000\uff0c20(1):25<\/p>\n<p>22. \u8303\u5c0f\u7d05\uff0c\u8463\u5f37\u525b\uff0c\u5305\u570b\u826f\uff0c\u7b49\u3002\u975e\u5c0f\u7d30\u80de\u80ba\u764c\u5916\u5468\u8840\u4e2d\u6a39\u7a81\u72c0\u7d30\u80de\u542b\u91cf\u964d\u4f4e\u53ca\u5176\u610f\u7fa9\u3002<em>\u816b\u7624<\/em>\uff0c2002\uff0c22(5):397-399<\/p>\n<p>23. \u4f55\u6b23\uff0c\u6731\u5b30\uff0c\u9ec3\u7acb\u4e2d\uff0c\u7b49\u3002\u6eab\u967d\u6563\u5bd2\u88dc\u6c23\u990a\u8840\u6cd5\u5c0d\u975e\u5c0f\u7d30\u80de\u80ba\u764c\u60a3\u8005\u5916\u5468\u8840\u6a39\u7a81\u72c0\u7d30\u80de\u5f71\u97ff\u7684\u7814\u7a76\u3002<em>\u4e2d\u570b\u4e2d\u91ab\u6025\u75c7<\/em>\uff0c2007\uff0c16(11):1308-1310<\/p>\n<p>24. \u90ce\u65ed\u5b87\uff0c\u90ed\u777f\uff0c\u5b8b\u7389\u862d\u3002\u80ba\u764c\u60a3\u8005\u570d\u624b\u8853\u671f\u8840\u6e05sIL-2R\u7684\u6aa2\u6e2c\u3002<em>\u5c71\u897f\u91ab\u79d1\u5927\u5b78\u5b78\u5831<\/em>\uff0c1997\uff0c18(4):315-317<\/p>\n<p>25. \u674e\u70af\uff0c\u6c88\u5fb7\u7fa9\uff0c\u9678\u5dcd\uff0c\u7b49\u3002\u76ca\u6c23\u990a\u9670\u65b9\u5c0d\u570d\u624b\u8853\u671f\u80ba\u764c\u60a3\u8005IL-2 sIL-2R\u7684\u5f71\u97ff\u3002<em>\u907c\u5be7\u4e2d\u91ab\u85e5\u96dc\u8a8c<\/em>\uff0c2007\uff0c34(7):907-908<\/p>\n<p>26. \u674e\u6d77\uff0c\u8d99\u589e\u864e\uff0c\u674e\u6210\u96f2\uff0c\u7b49\u3002\u5065\u813e\u76ca\u6c23\u990a\u8840\u4e2d\u85e5\u5c0d\u5316\u7642\u60a3\u8005\u5916\u5468\u8840\u5c0f\u677f\u5f71\u97ff\u3002<em>\u4e2d\u570b\u4e2d\u91ab\u6025\u75c7<\/em>\uff0c2006\uff0c15(6):599<\/p>\n<p>27. \u5468\u7559\u52c7\uff0c\u55ae\u73cd\u73e0\uff0c\u5c24\u5efa\u826f\u3002\u4e2d\u85e5\u5fae\u8abf\u56db\u865f\u65b9\u6cbb\u7642\u665a\u671f\u975e\u5c0f\u7d30\u80de\u80ba\u764c150\u4f8b\u3002<em>\u907c\u5be7\u4e2d\u91ab\u96dc\u8a8c<\/em>\uff0c2006\uff0c33(2):180-181<\/p>\n<p>28. \u5b5f\u5d1f\uff0c\u77f3\u6dd1\u73cd\uff0c\u7ac7\u5065\u537f\uff0c\u7b49\u3002\u4e2d\u85e5\u806f\u5408\u5316\u7642\u6cbb\u7642\u665a\u671f\u975e\u5c0f\u7d30\u80de\u80ba\u764c\u3002<em>\u907c\u5be7\u4e2d\u91ab\u96dc\u8a8c<\/em>\uff0c2006\uff0c33(11):1436<\/p>\n<p>29. 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\u67f4\u5c0f\u59dd\uff0c\u5433\u842c\u57a0\uff0c\u5f35\u6d77\u6ce2\uff0c\u7b49\u3002\u4e2d\u85e5\u806f\u5408\u9577\u6625\u745e\u6ff1\u6cbb\u7642\u8001\u5e74IIIB\/IV\u671f\u975e\u5c0f\u7d30\u80de\u80ba\u764c35\u4f8b\u3002<em>\u907c\u5be7\u4e2d\u91ab\u96dc\u8a8c<\/em>\uff0c2007\uff0c34(9):1258-1259<\/p>\n<p>33. \u5f35\u6dd1\u9999\u3002\u665a\u671f\u975e\u5c0f\u7d30\u80de\u80ba\u764c\uff08NSCLC\uff09\u7684\u8b49\u5019\u7814\u7a76\u3002<em>\u4e2d\u91ab\u85e5\u5b78\u520a<\/em>\uff0c2006\uff0c24(4):678-679<\/p>\n<p>34. \u5f35\u5fae\u5fae\uff0c\u9673\u8d8a\uff0c\u5f35\u6176\u8343\u3002\u6276\u6b63\u6291\u7624\u65b9\u5c0d\u665a\u671f\u975e\u5c0f\u7d30\u80de\u5316\u7642\u589e\u6548\u6e1b\u6bd2\u4f5c\u7528\u53caTSGF\u7684\u5f71\u97ff\u3002<em>\u4e0a\u6d77\u4e2d\u91ab\u85e5\u96dc\u8a8c<\/em>\uff0c2007\uff0c41(6):18-19<\/p>\n<p>35. \u5f35\u9298\uff0c\u5f90\u632f\u66c4\uff0c\u59dc\u552f\u6d01\u3002\u80ba\u5ca9\u5be7\u65b9\u5c0d\u665a\u671f\u975e\u5c0f\u7d30\u80de\u80ba\u764c\u60a3\u8005\u8840\u6e05\u8abf\u7bc0\u6027T\u7d30\u80deCD4+CD25+\u7684\u5f71\u97ff\u3002<em>\u907c\u5be7\u4e2d\u91ab\u96dc\u8a8c<\/em>\uff0c2006\uff0c33(8):916-917<\/p>\n<p>36. \u5f35\u9706\uff0c\u8cc8\u82f1\u6770\uff0c\u5f35\u8277\uff0c\u7b49\u3002\u5bc5\u6642\u7528\u53c3\u9ea5\u6db2\u5c0d\u975e\u5c0f\u7d30\u80de\u80ba\u764c\u60a3\u8005\u5316\u7642\u7684\u5f71\u97ff\u3002<em>\u907c\u5be7\u4e2d\u91ab\u96dc\u8a8c<\/em>\u30022007\uff0c34(8):1074-1076<\/p>\n<p>37. \u6881\u555f\u5ec9\uff0c\u5f35\u82f1\uff0c\u8b1d\u6770\u69ae\uff0c\u7b49\u3002\u8907\u65b9\u4e39\u53c3\u6ef4\u4e38\u806f\u5408\u5316\u7642\u6cbb\u7642\u4e2d\u665a\u671f\u975e\u5c0f\u7d30\u80de\u80ba\u764c\u7684\u81e8\u5e8a\u7814\u7a76\u3002<em>\u4e0a\u6d77\u4e2d\u91ab\u85e5\u96dc\u8a8c<\/em>\uff0c2007\uff0c41(1):22-24<\/p>\n<p>38. \u5289\u5609\u6e58\u3002\u80ba\u764c\u7684\u4e2d\u91ab\u85e5\u6cbb\u7642\u9032\u5c55\u3002<em>\u4e2d\u570b\u816b\u7624<\/em>\uff0c2002\uff0c11(6):326-329<\/p>\n<p>39. \u8a31\u5c24\u742a\uff0c\u4e01\u84c9\uff0c\u5f35\u7389\uff0c\u7b49\u3002\u4e2d\u85e5\u914d\u5408\u5316\u7642\u6cbb\u7642\u665a\u671f\u975e\u5c0f\u7d30\u80de\u80ba\u764c\u7642\u6548\u89c0\u5bdf\u3002<em>\u907c\u5be7\u4e2d\u91ab\u96dc\u8a8c<\/em>\uff0c2007\uff0c34(7):916-917<\/p>\n<p>40. \u90ed\u5349\uff0c\u7530\u83f2\uff0c\u8cc8\u6587\u5a1f\uff0c\u7b49\u3002\u897f\u9ec3\u4e38\u806f\u5408\u5316\u7642\u6cbb\u7642\u4e2d\u665a\u671f\u975e\u5c0f\u7d30\u80de\u80ba\u764c\u81e8\u5e8a\u89c0\u5bdf\u3002\u4e2d\u570b\u4e2d\u91ab\u6025\u75c7\uff0c2008\uff0c17(1):22-23<\/p>\n<p>41. 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Stetler Stevenson WG, Liotta LA, Kleiner DEJr. Extracellular matrix6: role of matrix metalloproteinases in tumour invasion and metastasis. <em>FASEBJ<\/em>, 1993, 7(15):1434-1441<\/p>\n<p>44. \u8212\u7426\u747e\uff0c\u738b\u5ef7\u7965\uff0c\u738b\u5f6c\u5f6c\uff0c\u7b49\u3002\u975e\u5c0f\u7d30\u80de\u80ba\u764c\u60a3\u8005\u8840\u6e05MMP-2 TIMP-2\u6c34\u5e73\u53ca\u9d09\u81bd\u5b50\u4e73\u5291\u7684\u8abf\u63a7\u4f5c\u7528\u3002<em>\u4e2d\u83ef\u4e2d\u91ab\u85e5\u5b78\u520a<\/em>\uff0c2007\uff0c25(8):1621-1624<\/p>\n<p>45. Thomas L. Discussion[A]. In: Lawrence HS. Cellular and humoral aspects of the hypersensitive states[M]. New York: Hoeber-Harper, 1959: 529-532<\/p>\n<p>46. Steinman RM, Mellman I. Immunotherapy: bewitched, bothered, and bewildered no more. <em>Science<\/em>, 2004, 305(5681):197-200<\/p>\n<p>47. Pawelec G. Immunotherapy and immunoselection-tumour escape as the final hurdle. <em>FEBS Lett<\/em>, 2004, 567(1):63-66<\/p>\n<p>48. \u9ec3\u96f2\u52dd\uff0c\u65bd\u5fd7\u660e\uff0c\u4e01\u91d1\u82b3\u3002\u76ca\u6c23\u990a\u9670\u6cd5\u5c0d\u80ba\u764c\u60a3\u8005\u5916\u5468\u8840\u816b\u7624\u514d\u75ab\u9003\u9038\u76f8\u95dc\u56e0\u5b50\u7684\u5f71\u97ff\u3002<em>\u4e0a\u6d77\u4e2d\u91ab\u85e5\u5927\u5b78\u5b78\u5831<\/em>\uff0c2007\uff0c21(3):48-51<\/p>\n<p>49. \u7fdf\u9577\u96f2\uff0c\u6731\u611b\u52e4\uff0c\u738b\u6649\u79cb\uff0c\u7b49\u3002\u4e2d\u85e5\u914d\u5408\u5316\u7642\u6cbb\u7642\u665a\u671f\u975e\u5c0f\u7d30\u80de\u80ba\u764c\u81e8\u5e8a\u89c0\u5bdf\u3002<em>\u907c\u5be7\u4e2d\u91ab\u96dc\u8a8c<\/em>\uff0c2005\uff0c32(12):1272<\/p>\n<p>50. 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